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Abstract #3146

Towards understanding of CEST signal in breast cancer; relation between APT- MT- and B1 effects.

Elles Elschot1, Lieke van den Wildenberg1, Vitaly Khlebnikov1, Dennis Klomp1, and Jannie Wijnen1
1Radiology Department, UMC Utrecht, Utrecht, Netherlands

This study investigates the relation between B1+ and signal amplitude of the APT and MT exchange pools in CEST MRI. We examined 19 breast cancer patients that underwent NAC treatment with CEST MRI at 7T. The data indicates evidence for an extra exchanging pool with strong B1 dependence, that is more abundant in tumor tissue compared to healthy tissue. By identifying the exchanging components in this pool, a new biomarker for tumor tissue could be found and used to understand changes in response to NAC early during treatment.

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