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Abstract #3145

An Analysis of Post-Radiation Response in DU145 Prostate Tumour Xenografts Using Magnetization Transfer MRI

Leedan Murray1, Wendy Oakden1, Wilfred W. Lam1, and Greg J. Stanisz1
1Physical Sciences, Sunnybrook Research Institute, Toronto, ON, Canada

The response to radiation treatment of DU145 prostate tumour xenografts was studied by comparing magnetization transfer-weighted Z-spectra before and after treatment. ROIs were drawn in homogenous sections of the tumour and analyzed based on corresponding TUNEL histology images. MTR decreased more than 1 week post-treatment in tumours that responded to treatment but was unchanged for non-responding tumours. The technique introduced in this study could potentially introduce a non-invasive way of determining treatment efficacy based on tumour necrosis/apoptosis.

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