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Abstract #3144

Distinguishing between macromolecular-driven magnetization transfer (MTSAT) and direct water saturation (MTDIR)

Dvir Radunsky1, Tamar Blumenfeld-Katzir1, and Noam Ben-Eliezer1,2,3
1Bio-medical Engineering, Tel Aviv University, Tel Aviv, Israel, 2Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel, 3Center for Advanced Imaging Innovation and Research (CAI2R), New-York University Langone Medical Center, New York, NY, United States

Mapping of T2 values is highly valuable for a wide range of applications. Still, accurate mapping is challenging due to the inherent bias of rapid Multi-Echo Spin-Echo (MESE) protocols by stimulated echoes, and also by magnetization transfer (MT). In this work, we investigate the different effects of macromolecular-driven MT (MTSAT) and direct water saturation (MTDIR) mechanisms on MESE signals, and their respective influence on T2 values. The investigation includes quantitative MT measurements between protocols with different scan settings and protocol schemes, aiming to isolate the individual roles of MTSAT and MTDIR.

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