Abstract #3148

Assessment of R2* dependency on fiber orientation and myelin concentration in normal-appearing white matter in multiple sclerosis

Renat Sibgatulin¹, Daniel Güllmar¹, Andreas Deistung², Stefan Ropele³, and Jürgen Rainer Reichenbach^1,4,5,6

¹Medical Physics Group, Institute of Diagnostic and Interventional Radiology, Jena University Hospital - Friedrich Schiller University Jena, Jena, Germany, ²Department of Radiology, University Hospital Halle (Saale), Halle, Germany, ³Department of Neurology, Medical University of Graz, Graz, Austria, ⁴Michael Stifel Center Jena for Data-Driven and Simulation Science, Friedrich Schiller University Jena, Jena, Germany, ⁵Abbe School of Photonics, Friedrich Schiller University Jena, Jena, Germany, ⁶Center of Medical Optics and Photonics, Friedrich Schiller University Jena, Jena, Germany

The effective transverse relaxation rate (R₂^*) is increasingly used in quantitative MRI, due to its sensitivity to iron and myelin content of the tissue. Separating the contributions from both sources is of particular interest in relation to multiple sclerosis. This work attempts to factor out contribution from myelin using orientation information derived from dMRI, and magnetization transfer saturation (MTS). Application of such correction to a group of multiple sclerosis patients and a control group, suggests that sensitivity of R₂^* to iron might be improved by accounting for fiber orientation in WM, while incorporation of MTS might not show clear benefit.

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