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Abstract #3160

Joint estimation of PDFF and T1 in abdomen with simultaneous B1+ correction at 3T

Hao Peng1,2, Liwen Wan1, Qian Wan1, Jianxun Lv1, Chuanli Cheng1, Xin Liu1, Hairong Zheng1, and Chao Zou1
1Shenzhen Institutes of Advanced Technology,Chinese Academy of Sciences, Shenzhen, China, 2Huazhong University of Science & Technology, Wuhan, China

T1 quantification is a valuable biomarker for liver function estimation and fibrosis staging. The presence of fat would confound the measurement of tissue T1. Chemical shift encoded fat-water separation combined variable flip angle (CSE-VFA) T1 mapping could remove the bias from fat signals, but B1 inhomogeneity would be a serious problem in abdominal applications. In this work, we proposed to combine the DREAM sequence with CSE-VFA, so that PDFF/T1/B1/R*2 could be simultaneously estimated. The deviation of the T1 values between the results with and without B1 correction verified the necessity of B1 measurements in the abdominal application.

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