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Abstract #3163

Simulating the effect of axonal dispersion and noise on anisotropic R2* relaxometry in white matter

Francisco Javier Fritz1, Luke J. Edwards2, Tobias Streubel1,2, Kerrin J. Pine2, Nikolaus Weiskopf2, and Siawoosh Mohammadi1,2
1Institute of System Neuroscience, Universitätklinikum Hamburg-Eppendorf, Hamburg, Germany, 2Department of Neurophysics, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany

We introduced a forward model to simulate the effect of fibre dispersion on the angle-dependent GRE signal decay in different SNR conditions. We compared the classical signal model against three variations of the signal model derived from a second-order Taylor expansion in time of Wharton and Bowtell’s HCFM model, including a new model that accounts for fibre dispersion. We found a noise enhancement in the model parameters when using the second-order models. Moreover, we found that the orientation dependency of the GRE signal diminished for high dispersions.

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