This work investigates tissue shrinkage during fixation and how it is related to associated changes in three quantitative MRI parameters (longitudinal relaxation $$$R_1$$$ and effective transverse relaxation $$$R_2^*$$$ rates, and magnetization transfer saturation rate MT). We proposed a new model to estimate tissue shrinkage from brain volume changes and found that shrinkage was $$$7.7\%$$$. No apparent relation between changes in MT and tissue shrinkage were found, whereas it was remarkable for $$$R_1$$$ and $$$R_2^*$$$, indicating that mostly the extra-axonal space is reduced during fixation.
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