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Abstract #3162

Quantification of tissue shrinkage due to formalin fixation of entire post-mortem human brain

Tobias Streubel1, Francisco Javier Fritz1, Herbert Mushumba2, Klaus PĆ¼schel2, and Siawoosh Mohammadi1
1Institute for Systems Neuroscience, University Medical Center Hamburg-Eppendorf, Hamburg, Germany, 2Institute of Legal Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

This work investigates tissue shrinkage during fixation and how it is related to associated changes in three quantitative MRI parameters (longitudinal relaxation $$$R_1$$$ and effective transverse relaxation $$$R_2^*$$$ rates, and magnetization transfer saturation rate MT). We proposed a new model to estimate tissue shrinkage from brain volume changes and found that shrinkage was $$$7.7\%$$$. No apparent relation between changes in MT and tissue shrinkage were found, whereas it was remarkable for $$$R_1$$$ and $$$R_2^*$$$, indicating that mostly the extra-axonal space is reduced during fixation.

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