Abstract #3167

Assessment of the sensitivity of inhomogeneous Magnetization Transfer (ihMT) brain imaging with B1+ variations at 3T

Lucas Soustelle^1,2, Samira Mchinda^1,2, Thomas Troalen³, Maxime Guye^1,2, Jean-Philippe Ranjeva^1,2, Gopal Varma⁴, David C Alsop⁴, Guillaume Duhamel^1,2, and Olivier M Girard^1,2

¹Aix-Marseille Univ, CNRS, CRMBM, Marseille, France, ²APHM, Hôpital Universitaire Timone, CEMEREM, Marseille, France, ³Siemens Healthcare SAS, Saint-Denis, France, ⁴Division of MR Research, Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States

Inhomogeneous Magnetization Transfer (ihMT) is a novel myelin imaging technique. As for many other MRI techniques special attention must be paid to local B₁⁺ variations in applications at high field. In this work, a detailed analysis of the ihMT ratio sensitivity to B₁⁺ inhomogeneities is performed in the context of human brain imaging at 3T. It is shown that concentrating RF power is an efficient way to reduce B₁⁺ induced bias and that the overall performance of the technique lies on a tradeoff between high ihMT ratios (sensitivity) and reduced sensitivity to B₁⁺ inhomogeneities.

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