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Abstract #3166

Quality assurance of multiparametric mri protocol for multi-centre prostate cancer sequential imaging clinical trial

Yu-Feng Wang1,2, Gary Liney2,3, Robba Rai2,3, Sirisha Tadimalla1, Jonathan Goodwin4, Lois Holloway2,3, and Annette Haworth1
1Institute of Medical Physics, The University of Sydney, Camperdown, Australia, 2Ingham Institute for Applied Medical Research, Liverpool, Australia, 3Liverpool and Macarthur Cancer Therapy Centre, Liverpool Hospital, Liverpool, Australia, 4Radiation Oncology Department, Calvary Mater Newcastle, Newcastle, Australia

Inter-/intra-scanner differences contribute to uncertainties in results from multi-centre longitudinal imaging studies. The Sequential Imaging Biofocussed Radiotherapy (SI-BiRT) trial is a multi-centre longitudinal imaging clinical trial that aims to develop imaging biomarkers using mpMRI to predict radiation therapy response in prostate cancer. Here we quantify the inter-/intra-scanner variabilities in the mpMRI protocol and scanners used in the SI-BiRT trial using commercial phantoms. ADC measurements were highly accurate while VFA T1 mapping overestimated reference values. ADC and T1 showed high intra-scanner reproducibility while R2* showed higher variability. The quantified uncertainties will be considered when interpreting results from the SI-BiRT trial.

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