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Abstract #3169

Exploring the anatomical variability in the precision of frequency difference mapping in the corpus callosum at 7T

Chiara Casella1, Elena Kleban1, and Derek K Jones1
1Department of Psychology, Cardiff University Brain Research Imaging Centre, Cardiff, United Kingdom

We explored the anatomical variability in reliability of complex mGRE signal, and of parameters estimated by modelling this signal as a superposition of complex myelin, intra- and extra-axonal water signals, in the corpus callosum at 7T. Our data showed to be repeatable in the posterior portion of the corpus callosum, while reliability was lower in more anterior portions. These findings have important implications and need to be considered when investigating callosal microstructure with mGRE in health and disease.

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