Meeting Banner
Abstract #3173

Reducing parameter estimate bias due to B1 field error ambiguity in CPMG MRI T2 relaxometry

Nick Zafeiropoulos1, Stephen Wastling1, Mary M Reilly2, Enrico De Vita3, Tarek Yousry1, and John Thornton1
1UCL Queen Square Institute of Neurology, London, United Kingdom, 2MRC Centre for Neuromuscular Diseases, London, United Kingdom, 3King's College London, London, United Kingdom

B1 field deviations above and below 100% of the nominal prescribed values have been noted by previous authors as a potential source of error in MRI CPMG T2 relaxometry. We show in simulations of clinically realistic acquisition protocols that this effect causes fit instability and loss of precision, and corroborate this with in vivo lower limb muscle image data. We then introduce a B1 error polarity spatial regularization scheme, and show that this improves parameter estimation accuracy.

This abstract and the presentation materials are available to members only; a login is required.

Join Here