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Abstract #3175

Effect of RF Pulse Duration on Chemical Shift Encoded MRI

Nathan Tibbitts Roberts1,2, Timothy Colgan1, and Scott B Reeder1,3,4,5,6
1Radiology, University of Wisconsin - Madison, Madison, WI, United States, 2Electrical and Computer Engineering, University of Wisconsin - Madison, Madison, WI, United States, 3Medical Physics, University of Wisconsin - Madison, Madison, WI, United States, 4Biomedical Engineering, University of Wisconsin - Madison, Madison, WI, United States, 5Medicine, University of Wisconsin - Madison, Madison, WI, United States, 6Emergency Medicine, University of Wisconsin - Madison, Madison, WI, United States

The effects of RF pulse duration on chemical shift encoded MRI (CSE-MRI) methods is a previously unexplored potential confounder for accurate and precise estimation of proton density fat fraction (PDFF) and R2*. Most signal models of CSE-MRI model RF excitation as instantaneous rotation of bulk magnetization; however, instantaneous excitation is not physically realizable. In this work we use Bloch equation simulations to characterize the effect of pulse duration on PDFF and R2* bias. We found that R2* bias was more sensitive than PDFF bias to RF pulse duration and note that clinically meaningful bias can be observed.

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