Abstract #3218

Liver iron content measurement in living mice with quantitative susceptibility mapping

Anton Abyzov¹, Joao Piraquive¹, Katell Peoc'h², Philippe Garteiser¹, and Bernard E. Van Beers¹

¹Laboratory of Imaging Biomarkers, Center of Research on Inflammation, UMR1149 Inserm-University Paris Diderot, Paris, France, ²Department of biochemistry, University Hospital Paris Nord - Beaujon, AP-HP, Clichy, France

To evaluate the feasibility of quantitative susceptibility mapping (QSM) in living mice liver and the robustness of QSM and transverse relaxation rate (R₂*) based liver iron quantification. We show that QSM can be accurately performed in mice liver despite respiratory motion and that magnetic susceptibility measurements correlate more strongly with inductively coupled plasma mass spectrometry (ICP-MS) based iron quantification and have smaller standard deviations and narrower Bland-Altman agreement limits than R₂* measurements.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.