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Abstract #3219

Using QSM to Quantify Microbubble Concentrations

Barbara Dymerska1, Bernard Siow2, and Karin Shmueli1
1Medical Physics and Biomedical Engineering, University College London, London, United Kingdom, 2Magnetic Resonance Imaging, The Francis Crick Institute, London, United Kingdom

Microbubbles are a well-established intravascular ultrasound contrast agent. There is increasing interest in MRI-guided microbubble-mediated focused ultrasound treatments such as thermal surgery. MRI magnitude has a non-linear and non-local dependence on microbubble size and volume fraction, making it unsuitable for estimating microbubble concentrations. Quantitative Susceptibility Mapping (QSM) is a strong candidate for tracking microbubble concentration, destruction and clearance because the susceptibility depends linearly on the volumetric bubble concentration. Here, we show the first QSM of microbubbles in a phantom and observe that the measured susceptibility has a high SNR and is directly proportional to the microbubble volumetric concentration.

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