Abstract #3220

Application of Fourier-domain Analysis Based Unwrapping Technique in Quantitative Susceptibility Mapping (QSM) of Intracerebral Hemorrhage

Ashmita De¹, Hongfu Sun¹, Kenneth S. Butcher², and Alan H. Wilman¹

¹Department of Biomedical Engineering, University of Alberta, Edmonton, AB, Canada, ²Division of Neurology, Department of Medicine, University of Alberta, Edmonton, AB, Canada

QSM offers a means to measure iron content changes in hemorrhage. However, the rapid T2* decay in hemorrhage causes a severe signal loss resulting in low SNR which cause failure of standard phase unwrapping in certain cases. Fourier-domain analysis based unwrapping technique may be useful to produce susceptibility maps of hemorrhages having low SNR. This method removes residual phase wraps resulting in artifact-free QSM with boundaries of the hemorrhage area more distinct to facilitate area measurement. Thus, this method can provide more precise susceptibility maps in cases where conventional unwrapping methods fail.

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