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Abstract #3220

Application of Fourier-domain Analysis Based Unwrapping Technique in Quantitative Susceptibility Mapping (QSM) of Intracerebral Hemorrhage

Ashmita De1, Hongfu Sun1, Kenneth S. Butcher2, and Alan H. Wilman1
1Department of Biomedical Engineering, University of Alberta, Edmonton, AB, Canada, 2Division of Neurology, Department of Medicine, University of Alberta, Edmonton, AB, Canada

QSM offers a means to measure iron content changes in hemorrhage. However, the rapid T2* decay in hemorrhage causes a severe signal loss resulting in low SNR which cause failure of standard phase unwrapping in certain cases. Fourier-domain analysis based unwrapping technique may be useful to produce susceptibility maps of hemorrhages having low SNR. This method removes residual phase wraps resulting in artifact-free QSM with boundaries of the hemorrhage area more distinct to facilitate area measurement. Thus, this method can provide more precise susceptibility maps in cases where conventional unwrapping methods fail.

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