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Abstract #3234

High-Efficient Metabolic Nano-Theranostics for MR Imaging and Cancer Therapy

Peng Wang1, Yaqiong Wang1, Jie Zhu2, Yong Zhang3, Ke-Xue Deng1, and Hui-Jun Dong1
1Radiology, The First Affiliated Hospital of University of Science and Technology of China, Hefei, China, 2Electronic information engineering, University of Aeronautics and Astronautics, Nanjing, China, 3GE Healthcare, Shanghai, China

In order to realize the nanotheranostics and reduce the toxicity of nanotheranostics agents to healthy tissues/organs, we constructed a novel nanotheranostics agents (Gd-DTPA-CS@β-CD@Dox) for MR imaging and Cancer treatment. Renal-clearable nanocomposites made it possible to overcome the long-term toxicity by accumulation in healthy living body. High uptake of the as-synthesized Gd-DTPA-CS@β-CD@Dox was achieved due to the longer blood circulation time. Moreover, the nanotheranostics agents possessed excellent performance in MRI. The nanotheranostics agents demonstrated a PH sensitive drug release. Such functional nanotheranostics agents applicable in highly integrated bio-modal imaging and multiple therapeutic functions may have great prospects in clinical practice.

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