Abstract #3235

4D Flow for estimation of global and local pulse wave velocity in stenotic femoral arteries

Ingo Hermann^1,2, Martin Sigl³, Stefan Schönberg⁴, Lothar R. Schad¹, and Frank G. Zöllner¹

¹Computer Assisted Clinical Medicine, Medical Faculty Mannheim, University Heidelberg, Mannheim, Germany, ²Magnetic Resonance Systems Lab, Department of Imaging Physics, Delft University of Technology, Delft, Netherlands, ³First Department of Medicine, Medical Faculty Mannheim, Mannheim, Germany, ⁴Institute of Clinical Radiology and Nuclear Medicine, Medical Faculty Mannheim, Mannheim, Germany

Pulse wave velocity (PWV) is a promising biomarker for decreasing artery diameter and wall stiffness. Recent work showed the possibility to calculate the local PWV from the velocity profil time delay along the artery out of 4D Flow measurements. In this study we used 4 different models (half maximum, maximum, foot-to-foot, cross-correlation) to compare and calculate the PWV in the relatively small femoral arteries in five subjects with stenotic arteries. We found an increased PWV of up to 20 m/s compared to literature values of healthy volunteers. Cross-correlation and half maximum methods yielded consistent results.

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