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Abstract #3237

Simultaneous Quantification of SPIO and Gd contrast agents using MR Fingerprinting

Anna Marriott1,2, Chris Bowen1,2, James Rioux1,2, and Kimberley Brewer1,2
1Biomedical Translational Imaging Centre (BIOTIC), HALIFAX, NS, Canada, 2Department of Physics & Atmospheric Science, Dalhousie University, HALIFAX, NS, Canada

Superparamagnetic Iron Oxide (SPIO) contrast agents are used extensively in molecular imaging studies as a tool to evaluate various SPIO-labelled cells. These studies would be greatly improved if multiple contrast agents could be quantified simultaneously. We combined an SSFP MR fingerprinting sequence with TE variation, and an extension of a concentration-dependent linear model, to achieve dual quantification and show viability of SPIO labelled CD8+ T cell mapping. As a pilot study for in vivo application, we demonstrate concentration mapping of a mouse injected with gadolinium, and R2* quantification of an SPIO labelled immune therapy injection site.

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