Abstract #3238

Vessel size imaging using hypoxia and hyperoxia gas challenges with spin- and gradient-echo (SAGE) MRI

Chau Vu¹, Jian Shen¹, and John C. Wood^1,2

¹Department of Biomedical Engineering, University of Southern California, Los Angeles, CA, United States, ²Departments of Pediatrics and Radiology, Children's Hospital Los Angeles, Los Angeles, CA, United States

This study demonstrated the feasibility of using hyperoxia and transient hypoxia gas challenges in conjunction with spin- and gradient-echo (SAGE) MRI to estimate vessel size index (VSI). Hypoxia yielded an average VSI of 14μm within acceptable range for healthy tissue, whereas hyperoxia severely underestimated vessel sizes. Test-retest in two patients demonstrated repeatability of hypoxia-VSI. Future work to optimize the acquisition and cross-validate against other VSI methodologies is required to assess the diagnostic value of this technique.

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