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Abstract #3239

In Vivo Myelin Quantification by T1w/T2w: Its Relationship with Other MRI Quantifiers of Myelin and Specificity

Hiroyuki Hamaguchi1, Nina Patzke2, Yuta Urushibata3, Xinnan Li1, Isabel Fernandez2, and Khin Khin Tha4,5
1Department of Biomarker Imaging Science, Hokkaido University Graduate School of Biomedical Science and Engineering, Sapporo, Japan, 2Department of Biological Sciences, Faculty of Science, Hokkaido University, Sapporo, Japan, 3Siemens Healthineers, Tokyo, Japan, 4Department of Diagnostic and Interventional Radiology, Hokkaido University Hospital, Sapporo, Japan, 5Global Station for Quantum Medical Science and Engineering, Hokkaido University, Sapporo, Japan

The division of T1-weighted image by T2-weighted image (T1w/T2w) has recently been introduced as a myelin quantifier, which gained attention due to the ease of obtaining images. However, controversy exists about its performance. The aim of this study was to test the correlation of T1w/T2w with other MRI quantifiers of myelin, so as to determine its performance. Moderate to strong correlation of T1w/T2w with the other quantifiers was observed. T1w/T2w appears to be sensitive to detect an abnormality, but is not specific for myelin.

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