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Abstract #3240

Accurate mapping of T2 relaxation times at low SNR, based on Bloch simulations and PCA image denoising

Neta Stern1, Dvir Radunsky1, Tamar Blumenfeld-Katzir1, and Noam Ben-Eliezer1,2,3
1Bio-medical Engineering, Tel Aviv University, Tel Aviv, Israel, 2Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel, 3Center for Advanced Imaging Innovation and Research (CAI2R), New-York University Langone Medical Center, New York, NY, United States

Quantitative T2 mapping using Bloch simulations offers high mapping accuracy, albeit may suffer from reduced precision due to noisy data when operating at low SNR.

In this work we tested the utility of PCA-based complex image denoising for increasing T2 mapping precision. Mapping was done using the echo modulation curve algorithm. Denoising was tested on phantom and in vivo scans. Comparing T2 maps before and after PCA complex image denoising showed an increase in T2 precision with no apparent loss of spatial resolution.

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