Abstract #3241

Rapid and Direct Quantification of Gadolinium from Blood using Time Resolved Fluorescence

James Tranos¹, Ayesha Bharadwaj Das¹, Zakia Ben Youss Gironda¹, Nora Butler¹, Jin Zhang¹, Stewart Russell², S. Gene Kim¹, and Youssef Zaim Wadghiri¹

¹Bernard & Irene Schwartz Center for Biomedical Imaging (CBI), Department of Radiology and Center for Advanced Imaging Innovation and Research (CAI2R), New York University School of Medicine, New York, NY, United States, ²Institute for Ultrafast Spectroscopy and Lasers, The City College of New York, New York, NY, United States

There are increasing needs to quantify the concentration of gadolinium for use in pharmacokinetic modeling, and traditional MR techniques prove to be inadequate. As an alternative, Time Resolved Fluorescence (TRF) can be used to directly measure the concentration of gadolinium, using a GBCA conjugated to a fluorescent antenna moiety. Here we show that TRF serves as a sensitive and direct approach to quantify the concentration of a sensitized GBCA, as a bifunctional contrast agent.

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