Abstract #3244

Biochemical Insights into the Molecular Mechanisms of Gadolinium Long-Term Deposition in the Human Body

Patrick Werner^1,2, Patrick Schuenke¹, Matthias Taupitz³, and Leif Schröder¹

¹Leibniz-Forschungsinstitut fuer Molekulare Pharmakologie, Berlin, Germany, ²BIOphysical Quantitative Imaging Towards Clinical Diagnosis (BIOQIC), Berlin, Germany, ³Department of Radiology, Charite Berlin, Berlin, Germany

The biochemical and molecular mechanisms of the gadolinium long-term deposition in biological tissues are widely unknown. In this study we prove that the observed hyperintensity of divined regions in the human body after clinical GBCA intervention can be caused by macromolecular species like glycosaminoglycans. We are able to show the importantance of sulfate groups and the influence of the sulfation state of these endogenous polysaccharides for this process by using MR relaxometry and isothermal titration calorimetry (ITC).

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