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Abstract #3245

Macromolecular Pool Fraction (MPF) Maps in Minimal Scan Time Using a Modified Fast SPGR Sequence and a Calibrated Synthetic MT Reference Image 

Kim Desmond1, Tobias C Wood2, and Sofia Chavez1
1CAMH, Toronto, ON, Canada, 2King's College, London, United Kingdom

MPF has been shown to correlate with myelin. Recent advances have reduced the required acquisitions to two: with (MTΔ) and without (MT0) the MT pulse. These, along with B1 and T1 maps, can be used to compute MPF. Scan time can be minimized by synthesizing MT0 from the T1 and B1 maps required for MPF mapping thus obviating the need to acquire MT0. Here we present advances that allow for MPF mapping in a minimal scan time (about 10 min) . These include optimizing B1 and T1 mapping implementations with calibration procedures to ensure accuracy and modifying an accelerated MT-prepared sequence.

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