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Abstract #3248

Signatures of microstructure in R2* decay: defining the limits of the weak field approximation

Pippa Storey1 and Dmitry S. Novikov1
1Department of Radiology, New York University School of Medicine, New York, NY, United States

R2* decay is nontrivial in the presence of magnetic microstructure; the logarithm of the signal is approximately quadratic over short times (the static dephasing regime) and asymptotically linear at long times (the diffusion narrowing regime). The transition can, in principle, provide an estimate of the characteristic length scales of the microstructure. Using Monte Carlo simulations of water molecules diffusing through a magnetic field perturbed by magnetic microstructure, we explore the regime of validity of the weak field approximation, in which the signal can be calculated analytically. We also illustrate how the signal behavior changes beyond the weak field limit.

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