Abstract #3249

On the Saturation Scheme in Chemical Exchange Saturation Transfer Imaging with B0 Inhomogeneity

Ruibin Liu¹, Qiuping Ding¹, Yi-Cheng Hsu², Yi Sun², Dan Wu¹, and Yi Zhang¹

¹Key Laboratory for Biomedical Engineering of Ministry of Education, Department of Biomedical Engineering, College of Biomedical Engineering & Instrument Science, Zhejiang University, Hangzhou, Zhejiang, China, ²MR Collaboration, Siemens Healthcare Ltd., Shanghai, China

Saturation pulses are an indispensable part in Chemical Exchange Saturation Transfer (CEST) imaging. Different saturation schemes can be designed for CEST imaging, including the pulse shape, duration of each pulse element, number of pulse elements, inter-pulse spoiler gradient, and inter-pulse gap, etc. Here, the impact of saturation schemes subject to practical B₀ inhomogeneity is investigated, using Bloch simulations, and phantom and human experiments. Specifically, it’s shown that Gaussian and rectangular saturation pulses demonstrate substantially different susceptibility to imaging artifacts in the presence of B₀ inhomogeneity when changing the duration of each saturation pulse element, and the inter-pulse spoiler gradients.

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