Abstract #3252

Quantitative susceptibility mapping with 1mm isotropic resolution in 2 minutes using compressed sensing

Arun Joseph^1,2,3, Tom Hilbert^4,5,6, Gabriele Bonanno^1,2,3, Emilie Mussard^4,5,6, Christoph Forman⁷, Ashley Stewart^8,9, Kieran O’Brien⁸, and Tobias Kober^4,5,6

¹Advanced Clinical Imaging Technology, Siemens Healthcare AG, Bern, Switzerland, ²Translational Imaging Center, Sitem-Insel, Bern, Switzerland, ³Departments of Radiology and Biomedical Research, University of Bern, Bern, Switzerland, ⁴Advanced Clinical Imaging Technology, Siemens Healthcare AG, Lausanne, Switzerland, ⁵Department of Radiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland, ⁶LTS5, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland, ⁷Siemens Healthcare AG, Erlangen, Germany, ⁸Siemens Healthcare Pty Ltd, Brisbane, Australia, ⁹Queensland Brain Institute, The University of Queensland, Brisbane, Australia

Quantitative susceptibility mapping exploits magnetic susceptibility to probe biological tissue. The obtained quantitative information carries additional clinical value, e.g. for the diagnosis of neurodegenerative diseases. However, standard protocols have long acquisition times which impedes their use in clinical routine. Here, we propose a compressed sensing acquisition based on a Cartesian spiral-phyllotaxis readout scheme to drastically reduce the total acquisition times from 20 minutes to 2 minutes for a 1mm isotropic susceptibility map of the whole brain. A preliminary qualitative and quantitative validation is performed on healthy subjects.

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