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Abstract #3252

Quantitative susceptibility mapping with 1mm isotropic resolution in 2 minutes using compressed sensing

Arun Joseph1,2,3, Tom Hilbert4,5,6, Gabriele Bonanno1,2,3, Emilie Mussard4,5,6, Christoph Forman7, Ashley Stewart8,9, Kieran O’Brien8, and Tobias Kober4,5,6
1Advanced Clinical Imaging Technology, Siemens Healthcare AG, Bern, Switzerland, 2Translational Imaging Center, Sitem-Insel, Bern, Switzerland, 3Departments of Radiology and Biomedical Research, University of Bern, Bern, Switzerland, 4Advanced Clinical Imaging Technology, Siemens Healthcare AG, Lausanne, Switzerland, 5Department of Radiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland, 6LTS5, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland, 7Siemens Healthcare AG, Erlangen, Germany, 8Siemens Healthcare Pty Ltd, Brisbane, Australia, 9Queensland Brain Institute, The University of Queensland, Brisbane, Australia

Quantitative susceptibility mapping exploits magnetic susceptibility to probe biological tissue. The obtained quantitative information carries additional clinical value, e.g. for the diagnosis of neurodegenerative diseases. However, standard protocols have long acquisition times which impedes their use in clinical routine. Here, we propose a compressed sensing acquisition based on a Cartesian spiral-phyllotaxis readout scheme to drastically reduce the total acquisition times from 20 minutes to 2 minutes for a 1mm isotropic susceptibility map of the whole brain. A preliminary qualitative and quantitative validation is performed on healthy subjects.

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Abstract