Abstract #3253

Identifying Different Types of Local Lesions in the Lenticular Nucleus of Patients with Wilson’s Disease using Quantitative Susceptibility Maps

Gaiying Li¹, Rong Wu², Yasong Du³, Kelly M Gillen⁴, Yi Wang⁴, Xiaoping Wang², and Jianqi Li¹

¹East China Normal University, Shanghai, China, ²Shanghai Tong-Ren Hospital, Shanghai, China, ³Shanghai Mental Health Center, Shanghai, China, ⁴Weill Medical College of Cornell University, New York, NY, United States

The objective of this study was to discriminate signal changes of edema, encephalomalacia and excessive metal deposition in the lenticular nucleus of patients with Wilson’s Disease on quantitative susceptibility maps. Standard T1- weighted, T2- weighted, T2 FLAIR and QSM images were obtained on 14 WD subjects using 3T MRI. The results indicated that QSM could effectively discriminate different types of local lesions, including metal deposition hyperintensity, encephalomalacia hypointensity, and edema medium intensity. Furthermore, our study revealed that UWDRS and neurological symptoms scores of patients with severe abnormal MRI manifestations were significantly higher than that of patients with mild abnormal MRI.

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