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Abstract #3254

Detection of Iron Deposition in Substantia Nigra for Mouse of Parkinson’s Disease: A Comparison of Quantitative Susceptibility Mapping and R2*

Yihao Guo1,2, Jijing Guan1, Jinghui Xu3, Wenbin Si1, Yingjie Mei4, Qianjian Feng1,2, Yunqi Xu3, and Yanqiu Feng1,2
1School of Biomedical Engineering, Southern Medical University, Guagnzhou, China, 2Guangdong Provincial Key Laboratory of Medical Image Processing, Southern Medical University, Guagnzhou, China, 3Department of Neurology, Nanfang Hospital, Southern Medical University, Guangzhou, China, 4Philips Healthcare, Guangzhou, China

Parkinson’s disease (PD), a common neurodegenerative disorder, is associated with iron deposition in the substantial nigra (SN) of both human and animal models. SN iron is a potential biomarker for diagnosing and monitoring PD. The aim of this study was to compare QSM and R2* for quantifying SN iron in mouse brain.

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