Abstract #3254

Detection of Iron Deposition in Substantia Nigra for Mouse of Parkinson’s Disease: A Comparison of Quantitative Susceptibility Mapping and R2*

Yihao Guo^1,2, Jijing Guan¹, Jinghui Xu³, Wenbin Si¹, Yingjie Mei⁴, Qianjian Feng^1,2, Yunqi Xu³, and Yanqiu Feng^1,2

¹School of Biomedical Engineering, Southern Medical University, Guagnzhou, China, ²Guangdong Provincial Key Laboratory of Medical Image Processing, Southern Medical University, Guagnzhou, China, ³Department of Neurology, Nanfang Hospital, Southern Medical University, Guangzhou, China, ⁴Philips Healthcare, Guangzhou, China

Parkinson’s disease (PD), a common neurodegenerative disorder, is associated with iron deposition in the substantial nigra (SN) of both human and animal models. SN iron is a potential biomarker for diagnosing and monitoring PD. The aim of this study was to compare QSM and R2* for quantifying SN iron in mouse brain.

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