This study describes a new dual-injection, dual-temporal resolution (DTR) DCE-MRI mapping technique, which performs first-pass adjustment (FAD) of pre-bolus uptake curves using enhancement patterns measured from a main-dose, high-spatial resolution DCE acquisition. This new technique permits derivation of whole brain, super-spatial resolution kinetic parameter maps and its clinical applicability in vivo was assessed through application to retrospective DTR-DCE-MRI data from 12 NF2 patients undergoing Avastin therapy. Compared to the classical DTR-DCE-FDHS, method, baseline Ktrans derived using the FAD technique demonstrated superior ability in the prediction of 90 day volumetric response in Avastin treated NF2 related VS.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords