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Abstract #3260

A Novel Approach Using First-Pass Adjusted DTR-DCE-MRI (FAD) for Accurate Super-Spatial Resolution Brain Pharmacokinetic Parametric Mapping

Xiaoping Zhu1, Daniel Lewis2, Sha Zhao1, Alan Jackson1, and Ka-Loh Li1
1DIIDS, University of Manchester, Manchester, United Kingdom, 2Salford Royal NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, United Kingdom

This study describes a new dual-injection, dual-temporal resolution (DTR) DCE-MRI mapping technique, which performs first-pass adjustment (FAD) of pre-bolus uptake curves using enhancement patterns measured from a main-dose, high-spatial resolution DCE acquisition. This new technique permits derivation of whole brain, super-spatial resolution kinetic parameter maps and its clinical applicability in vivo was assessed through application to retrospective DTR-DCE-MRI data from 12 NF2 patients undergoing Avastin therapy. Compared to the classical DTR-DCE-FDHS, method, baseline Ktrans derived using the FAD technique demonstrated superior ability in the prediction of 90 day volumetric response in Avastin treated NF2 related VS.

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