The injection protocol used in carotid dynamic contrast-enhanced (DCE) MRI varies among different studies. The effect of the injection protocol on carotid black-blood and interleaved black-bright-blood DCE sequences were evaluated in this study. The results demonstrated that high injection dose (~ 0.1mmol/kg) with relative low effective injection rate (< 0.3mmol/s) was recommended for the simulated black-blood and interleaved black-bright-blood sequences. These two sequences were also shown to be insensitive to the uncertain time gap between the contrast injection and the post-contrast image acquisition.
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