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Abstract #3261

Optimization of the Injection Protocol for Carotid Black-blood and Interleaved Black-bright-blood Dynamic Contrast-Enhanced MRI

Yajie Wang1, Yishi Wang2, Xian Liu1, and Huijun Chen1
1Center for Biomedical Imaging Research, School of Medicine, Tsinghua University, Beijing, China, 2Philips Healthcare, Beijing, China

The injection protocol used in carotid dynamic contrast-enhanced (DCE) MRI varies among different studies. The effect of the injection protocol on carotid black-blood and interleaved black-bright-blood DCE sequences were evaluated in this study. The results demonstrated that high injection dose (~ 0.1mmol/kg) with relative low effective injection rate (< 0.3mmol/s) was recommended for the simulated black-blood and interleaved black-bright-blood sequences. These two sequences were also shown to be insensitive to the uncertain time gap between the contrast injection and the post-contrast image acquisition.

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