In $$$T_1$$$-weighted perfusion studies, the relationship between the contrast concentration and $$$T_1$$$ shortening effect is assumed to be linear within the clinical range. However, this assumption may not hold at higher concentration observed in the arterial input functions (AIFs). We set out to investigate this relationship by measuring the $$$R_1$$$ relaxation rate of various Gd-DTPA concentrations in saline. We find that the change in $$$R_1$$$ relaxation rate of Gd-DTPA is linear up to 4 mM at 9.4T and 11.7T, and up to 5 mM at 3T. At higher concentration, $$$R_1$$$ relaxation rate increases faster than a linear relationship.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords