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Abstract #3267

ASL perfusion imaging predicts cognitive impairment in cerebral small vessel disease

Joana Pinto1, Ana Fouto1, Rita G. Nunes1, Luísa Alves2, Sofia Calado2, Carina Gonçalves2, Margarida Rebolo3, Miguel Viana Baptista2, Pedro Vilela4, and Patrícia Figueiredo1
1ISR-Lisboa/LARSyS and Department of Bioengineering, Instituto Superior Técnico – Universidade de Lisboa, Lisboa, Portugal, 2Neurology Department, Hospital Egas Moniz, Centro Hospitalar de Lisboa Ocidental; CEDOC - Nova Medical School, New University of Lisbon, Lisboa, Portugal, 3Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal, 4Imaging Department, Hospital da Luz, Lisboa, Portugal

Cerebral small vessel disease (SVD) is one of the most common vascular causes of dementia, and a major contributor of age-related cognitive decline. We evaluated cerebral perfusion using arterial spin labeling (ASL), in terms of its predictive power of cognitive impairment in a group of SVD patients. We employed a multiple-delay pulsed ASL acquisition and fitted an extended kinetic model to the signal in order to derive cerebral blood flow (CBF) as well as bolus arrival time (BAT) maps. Regression analysis demonstrated that CBF in gray matter (GM) significantly contributed to explaining cognitive impairments in processing speed.

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