Statin treatment is considered as an effective method to stabilize atherosclerosis and potentially improve cerebral perfusion. This study evaluated the changes of artery stenosis and CBF on arterial spin labeling during statin treatment with two-years’ follow-up. We found that CBF improved in the symptomatic territory among all subjects at 6th month (rCBF: 0.92±0.07 vs. 0.95±0.07, P=0.001). After 6 months, however, CBF decreased in patients with stenosis progression whereas maintained at a stable level in patients with stenosis regression, suggesting that changes of symptomatic MCA stenosis may have an effect on the cerebral hemodynamic improvements during statin treatment in different stages.
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