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Abstract #3265

Dynamic arterial spin labeling MRI of cerebrovascular perfusion during exercise

Isa Mast1,2, Koen P.A. Baas2, Aart J. Nederveen2, and Adrianus J. Bakermans2
1Human Movement Sciences, Vrije Universiteit van Amsterdam, Amsterdam, Netherlands, 2Radiology and Nuclear Medicine, Amsterdam UMC, Amsterdam, Netherlands

Pathophysiological changes in cerebrovascular reactivity can remain undetectable at rest, and may only become apparent during a cerebrovascular challenge. We evaluated the feasibility of dynamically measuring the cerebrovascular response to exercise using pseudo-continuous arterial spin labeling (pCASL) at 3 Tesla during a bicycle exercise-recovery stress test. We observed a transient increase in cerebrovascular blood flow (CBF) during exercise in four volunteers, demonstrating that pCASL-MRI can capture dynamic changes in CBF during physiological bicycle exercise. This approach may become an important quantitative tool to noninvasively investigate the cerebrovascular reactivity in health and disease.

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