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Abstract #3264

Optimization of Pseudo Continuous Arterial Spin Labeling for measuring perfusion in CKD patients

Rebeca Echeverria-Chasco1, Marta Vidorreta2, VerĂ³nica Aramendia-Vidaurreta1, Nuria Garcia-Fernandez3, Gorka Bastarrika1, and Maria A. Fernandez-Seara1
1Radiology, Clinica Universidad de Navarra, Pamplona, Spain, 2Siemens Healthineers, Madrid, Spain, 3Nephrology, Clinica Universidad de Navarra, Pamplona, Spain

The main goal of this work was to optimize the robustness of pseudo continuous Arterial Spin Labeling (pCASL) to acquire renal images in CKD patients. The optimization was firstly carried out through numerical simulations, and a pCASL experiment in healhty volunteers to assess the veracity of the simulations. The results were in agreeement with the simulations (p-value = 0.04). For CKD patients, the numerical simulations were made to select the parameters that maximize the efficiency. The results for CKD patients and controls that show highest efficiencies are ratios 6-7 and Gave of 0.5-0.7 mT/m.

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