The main goal of this work was to optimize the robustness of pseudo continuous Arterial Spin Labeling (pCASL) to acquire renal images in CKD patients. The optimization was firstly carried out through numerical simulations, and a pCASL experiment in healhty volunteers to assess the veracity of the simulations. The results were in agreeement with the simulations (p-value = 0.04). For CKD patients, the numerical simulations were made to select the parameters that maximize the efficiency. The results for CKD patients and controls that show highest efficiencies are ratios 6-7 and Gave of 0.5-0.7 mT/m.