Age is an important risk factor for cerebrovascular disease. ASL can lend different insights depending on the choice of read-out (3D or 2D) and post-label-delay (PLD) for instance. We assessed differences in cerebral blood flow (CBF), and investigated the added value of arterial transit time (ATT) for differentiating older from younger healthy volunteers. Single-PLD 2D-pCASL and time-encoded (te-)ASL had almost identical CBF, while multi-PLD te-ASL offered the additional option to estimate ATT and blood volume. We found prolonged ATT despite unaffected CBF in older versus younger volunteers. TE-ASL could therefore provide ‘free’ information aside from perfusion in clinical settings.
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