Abstract #3270

Time-encoded ASL provides added value in differentiating healthy older from younger individuals compared to single time-point methods

Lena Vaclavu¹, Carles Falcon ², Paula Montesinos ³, Kim van de Ven⁴, Juan Domingo Gispert ², and Matthias J.P. van Osch¹

¹Department of Radiology, Leiden University Medical Center, Leiden, Netherlands, ²Pasqual Maragall Foundation, Barcelonaβeta Brain Research Center (BBRC), Barcelona, Spain, ³Philips Iberia, Madrid, Spain, ⁴Philips, Best, Netherlands

Age is an important risk factor for cerebrovascular disease. ASL can lend different insights depending on the choice of read-out (3D or 2D) and post-label-delay (PLD) for instance. We assessed differences in cerebral blood flow (CBF), and investigated the added value of arterial transit time (ATT) for differentiating older from younger healthy volunteers. Single-PLD 2D-pCASL and time-encoded (te-)ASL had almost identical CBF, while multi-PLD te-ASL offered the additional option to estimate ATT and blood volume. We found prolonged ATT despite unaffected CBF in older versus younger volunteers. TE-ASL could therefore provide ‘free’ information aside from perfusion in clinical settings.

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