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Abstract #3270

Time-encoded ASL provides added value in differentiating healthy older from younger individuals compared to single time-point methods

Lena Vaclavu1, Carles Falcon 2, Paula Montesinos 3, Kim van de Ven4, Juan Domingo Gispert 2, and Matthias J.P. van Osch1
1Department of Radiology, Leiden University Medical Center, Leiden, Netherlands, 2Pasqual Maragall Foundation, Barcelonaβeta Brain Research Center (BBRC), Barcelona, Spain, 3Philips Iberia, Madrid, Spain, 4Philips, Best, Netherlands

Age is an important risk factor for cerebrovascular disease. ASL can lend different insights depending on the choice of read-out (3D or 2D) and post-label-delay (PLD) for instance. We assessed differences in cerebral blood flow (CBF), and investigated the added value of arterial transit time (ATT) for differentiating older from younger healthy volunteers. Single-PLD 2D-pCASL and time-encoded (te-)ASL had almost identical CBF, while multi-PLD te-ASL offered the additional option to estimate ATT and blood volume. We found prolonged ATT despite unaffected CBF in older versus younger volunteers. TE-ASL could therefore provide ‘free’ information aside from perfusion in clinical settings.

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