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Abstract #3271

Arterial spin labeling signal in the Sagittal Sinus as hemodynamic proxy parameter in patients with sickle cell disease.

Liza Afzali-Hashemi1, Lena Vaclavu2, Jan Petr3, John Wood4, Bart J Biemond5, Aart J Nederveen6, and Henk JMM Mutsaerts7
1Radiology and Nuclear Medicine, Amsterdam University Medical Center, location AMC, Amsterdam, Netherlands, 2Radiology, Leiden University Medical Center, Leiden, Netherlands, 3Helmholtz-Zentrum Dresden-Rossendorf, Institute of Radiopharmaceutical Cancer Research, Dresden, Germany, 4Department of Cardiology and Radiology, Children’s Hospital of Los Angeles, Los Angeles, CA, United States, 5Department of Hematology, Amsterdam UMC, location AMC, Amsterdam, Netherlands, 6Department of Radiology & Nuclear Medicine, Amsterdam UMC, location AMC, Amsterdam, Netherlands, 7Amsterdam UMC, Amsterdam, Netherlands

Higher sagittal sinus signal is present in the ASL images of patients with sickle cell disease (SCD). The purpose of this study was to assess if the signal in the sagittal sinus is correlated with clinical parameters and if this is affected by the vasoactive stimulus. The sagittal sinus signal was measured in patients with SCD and in healthy controls. Signal in sagittal sinus of the SCD patients were significantly correlated with clinical parameters including hemolysis markers. Our results show that sagittal sinus signal can be used as a hemodynamic proxy parameter in patients with SCD.

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