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Abstract #3272

DW-pCASL measure of BBB water permeability is sensitive to pharmacological manipulation of AQP4 function

Hsiao-Ying Wey1, Xingfeng Shao2, and Danny JJ Wang2
1Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, United States, 2USC Stevens Neuroimaging and Informatics Institute, University of Southern California, Los Angeles, CA, United States

The blood-brain barrier (BBB) is a tightly regulated structure that protect the central nervous system (CNS). BBB impairment is implicated in several brain disorders, such as Alzheimer’s disease. Aquaporin-4 (AQP4) water channels are critically involved in regulating brain water transport across the BBB. We have recently developed a diffusion-weighted pCASL (DW-pCASL) technique allowing measurement of water permeability across the BBB. In this study, we implemented and optimized DW-pCASL in nonhuman primates. We directly validated that the underlying signal mechanism of DW-pCASL is related to AQP4-mediated BBB water exchange using a pharmacological challenge.

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