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Abstract #3273

Reliability and Reproducibility of ASL-MRI Measured Perfusion in GBM at 3T

Limin Zhou1, Yiming Wang1, Marco Da Cunha Pinho1,2, Edward Pan3,4,5, Joseph Maldjian1,2, Yin Xi1,6, and Ananth Madhuranthakam1,2
1Radiology, University of Texas Southwestern Medical Center, Dallas, TX, United States, 2Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, United States, 3Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX, United States, 4Neurological Surgery, University of Texas Southwestern Medical Center, Dallas, TX, United States, 5Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center, Dallas, TX, United States, 6Population and Data Sciences, University of Texas Southwestern Medical Center, Dallas, TX, United States

We have assessed the reliability of pCASL using 3D TSE-CASPR in healthy volunteers and glioblastoma (GBM) patients. “Excellent” agreement was observed for intrasession reliability in both normal appearing grey matter (NAGM) and tumors with intraclass correlation coefficient (ICC) of 0.945 (95% CI: 0.916-0.964) and 0.948 (95% CI: 0.883-0.978) respectively. Across multiple ROIs, the within-subject coefficient of variation (wsCV) was measured to be 6.1 ± 1.2% across all subjects in NAGM, and 5.1% in tumors. The lower wsCV in tumors allow 3D TSE pCASL using CASPR to be used for longitudinal monitoring of GBM patients.

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