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Abstract #3274

Reducing the effect of cerebrospinal fluid pulsation on arterial spin labeled perfusion MRI acquired with fast spin echo readouts

Jianxun Qu1, Tianye Lin1,2, Karthik Prabhakaran3, M. Dylan Tisdall1, and John A. Detre1,3
1Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States, 2Chinese Academy of Medical Sciences, Peking Union Medical College, PUMCH, Beijing, China, 3Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States

Fast spin echo is widely used for ASL acquisition. However, if the flip angle reduced to minimize SAR and/or stabilize signal evolution over the echo train, the fluctuation of CSF increases markedly. This work explored the influence of minimum flip angle, and crusher strength in ASL acquisition. A CSF-prioritized background suppression (BS) planning was also performed. We found that increasing minimum flip angle together with reducing crusher in superior-inferior direction benefits the stability of ASL acquisitions. Prioritizing CSF suppression in BS was also helpful.

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