Abstract #3274

Reducing the effect of cerebrospinal fluid pulsation on arterial spin labeled perfusion MRI acquired with fast spin echo readouts

Jianxun Qu¹, Tianye Lin^1,2, Karthik Prabhakaran³, M. Dylan Tisdall¹, and John A. Detre^1,3

¹Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States, ²Chinese Academy of Medical Sciences, Peking Union Medical College, PUMCH, Beijing, China, ³Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States

Fast spin echo is widely used for ASL acquisition. However, if the flip angle reduced to minimize SAR and/or stabilize signal evolution over the echo train, the fluctuation of CSF increases markedly. This work explored the influence of minimum flip angle, and crusher strength in ASL acquisition. A CSF-prioritized background suppression (BS) planning was also performed. We found that increasing minimum flip angle together with reducing crusher in superior-inferior direction benefits the stability of ASL acquisitions. Prioritizing CSF suppression in BS was also helpful.

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