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Abstract #3275

Improved inflow saturation markedly reduces inflow artifacts in background-suppressed 3D arterial spin labeling

Jianxun Qu1, Tianye Lin1,2, Priti Balchandani3, M. Dylan Tisdall1, and John A. Detre1,4
1Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States, 2Chinese Academy of Medical Sciences, Peking Union Medical College, PUMCH, Beijing, China, 3Icahn School of Medicine at Mount Sinai, New York, NY, United States, 4Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States

Inflow blood during the post labeling delay is a significant source of physiological noise in arterial spin labeling. This study utilized a novel inflow saturation method to address this issue. Compared to traditional inflow saturation approach where a 90o thick saturation slab is used to null blood within the interval of background suppression inversion pulses, the proposed method employs serial of thin slab sub-bolus saturations, with the saturation strength planned adaptively to return the blood to nulling point at the excitation point. The proposed method reduces the inflow artifacts markedly and mitigates global signal fluctuations.

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