Inflow blood during the post labeling delay is a significant source of physiological noise in arterial spin labeling. This study utilized a novel inflow saturation method to address this issue. Compared to traditional inflow saturation approach where a 90o thick saturation slab is used to null blood within the interval of background suppression inversion pulses, the proposed method employs serial of thin slab sub-bolus saturations, with the saturation strength planned adaptively to return the blood to nulling point at the excitation point. The proposed method reduces the inflow artifacts markedly and mitigates global signal fluctuations.
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