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Abstract #3276

Off-resonance and flow-velocity immune ASL at low-power using pseudo-continuous saturation labeling

Manuel Taso1 and David C. Alsop1
1Division of MRI research, Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States

While widely used for perfusion imaging, the flow-driven inversion labeling commonly used with pseudo-continuous ASL (PCASL) presents a significant off-resonance sensitivity as well as high power deposition potentially limiting high-field applications. We therefore investigated an alternate labeling scheme that takes advantage of the multiple aliased labeling planes that arise within the labeling RF envelope when reducing the peak-to-average gradient ratio. First numerical simulations and experiments show the potential for low-SAR, B0 and flow-velocity robust saturation labeling.

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