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Abstract #3278

High-resolution whole brain perfusion mapping in mice by a drift-corrected steady pulsed imaging and labeling sequence

Wenjing Xu1,2, Jiadi Xu3,4, and Xiaoyong Zhang1,2
1Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China, 2Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence (Fudan University), Ministry of Education, Shanghai, China, 3Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 4F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States

We developed a drift-corrected steady pulsed imaging and labeling (dSPIL) to measure CBF with high-resolution and whole brain coverage. We applied a metric of low band pass to remove MRI signal drift using interleaved label-control images. We also optimized several key imaging parameters in an effort to minimize scan time while covering the whole brain. With the optimized dSPIL scheme, quantification of high-resolution CBF in 22 mouse brain regions can be obtained. As a demonstration and validation of the method, the volume of ischemic lesion regions in mice was quantified by calculating CBF reductions.

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