Abstract #3278

High-resolution whole brain perfusion mapping in mice by a drift-corrected steady pulsed imaging and labeling sequence

Wenjing Xu^1,2, Jiadi Xu^3,4, and Xiaoyong Zhang^1,2

¹Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China, ²Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence (Fudan University), Ministry of Education, Shanghai, China, ³Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ⁴F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States

We developed a drift-corrected steady pulsed imaging and labeling (dSPIL) to measure CBF with high-resolution and whole brain coverage. We applied a metric of low band pass to remove MRI signal drift using interleaved label-control images. We also optimized several key imaging parameters in an effort to minimize scan time while covering the whole brain. With the optimized dSPIL scheme, quantification of high-resolution CBF in 22 mouse brain regions can be obtained. As a demonstration and validation of the method, the volume of ischemic lesion regions in mice was quantified by calculating CBF reductions.

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