This study introduces a subject-specific automated approach for optimization of background suppression (BS) in 3D pseudo-continuous arterial spin labeling perfusion imaging. Optimised timing of BS related FOCI pulses is calculated from the T1 spectrum, obtained from a M0 scan of the organ of interest. Results show strong suppression of brain tissue, when magnetization is nulled at the time of excitation as well as high quality perfusion images, when a slight delay between nullpoint and excitation is introduced for different numbers of FOCI pulses.
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