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Abstract #3287

Examination of optimised PLD protocols for pCASL: accounting for dispersion and macrovascular contamination over a prolonged ATT range

Xin Logan Zhang1, Joseph G. Woods1,2, Flora Kennedy McConnell1, Thomas W. Okell1, and Michael A. Chappell1
1Institute of Biomedical Engineering & Wellcome Centre for Integrative Neuroimaging, University of Oxford, Oxford, United Kingdom, 2Department of Radiology, University of California San Diego, La Jolla, CA, United States

A general framework has been proposed for optimising PLD sampling protocols in pCASL under an ideal kinetic model. In this study, the performance of CBF and ATT estimation of two optimised protocols CBF-ATTopt and CBFopt, along with a reference multi-PLD and single-PLD protocol, was investigated using simulations and in vivo when accounting for dispersion and macrovascular contamination (MVC) over a prolonged ATT range. CBFopt showed the least sensitivity among all protocols for CBF estimation when ATT was prolonged and when MVC was present. Future work can optimise for both macrovascular component and tissue component with a prolonged ATT range.

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