Abstract #3287

Examination of optimised PLD protocols for pCASL: accounting for dispersion and macrovascular contamination over a prolonged ATT range

Xin Logan Zhang¹, Joseph G. Woods^1,2, Flora Kennedy McConnell¹, Thomas W. Okell¹, and Michael A. Chappell¹

¹Institute of Biomedical Engineering & Wellcome Centre for Integrative Neuroimaging, University of Oxford, Oxford, United Kingdom, ²Department of Radiology, University of California San Diego, La Jolla, CA, United States

A general framework has been proposed for optimising PLD sampling protocols in pCASL under an ideal kinetic model. In this study, the performance of CBF and ATT estimation of two optimised protocols CBF-ATT_opt and CBF_opt, along with a reference multi-PLD and single-PLD protocol, was investigated using simulations and in vivo when accounting for dispersion and macrovascular contamination (MVC) over a prolonged ATT range. CBF_opt showed the least sensitivity among all protocols for CBF estimation when ATT was prolonged and when MVC was present. Future work can optimise for both macrovascular component and tissue component with a prolonged ATT range.

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