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Abstract #3286

Investigating the Repeatability of Cerebrovascular Reactivity Using Single and Multi-PLD PCASL

Moss Y Zhao1, Audrey P Fan1, David Yen-Ting Chen1,2, David D Shin3, Mohammad Mehdi Khalighi1, Dawn Holley1, Kim Halbert1, Andrea Otte1, Brittney Williams1, Jun-Hyung Park1, Bin Shen1, and Greg Zaharchuk1
1Department of Radiology, Stanford University, Stanford, CA, United States, 2Department of Radiology, Shuang-Ho Hospital, Taipei Medical University, Taipei, Taiwan, 3GE Healthcare, Menlo Park, CA, United States

This work investigates the repeatability of CVR (induced by acetazolamide) using ASL on a healthy cohort. Single and multi-PLD PCASL data were collected before and after the administration of acetazolamide in two identical sessions. Results showed that the mean CVR of both ASL techniques were between 20% and 60% and not significantly different. Measurement using single-PLD PCASL demonstrated higher repeatability based on a lower coefficient of variation and a higher intraclass correlations.

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