Abstract #3286

Investigating the Repeatability of Cerebrovascular Reactivity Using Single and Multi-PLD PCASL

Moss Y Zhao¹, Audrey P Fan¹, David Yen-Ting Chen^1,2, David D Shin³, Mohammad Mehdi Khalighi¹, Dawn Holley¹, Kim Halbert¹, Andrea Otte¹, Brittney Williams¹, Jun-Hyung Park¹, Bin Shen¹, and Greg Zaharchuk¹

¹Department of Radiology, Stanford University, Stanford, CA, United States, ²Department of Radiology, Shuang-Ho Hospital, Taipei Medical University, Taipei, Taiwan, ³GE Healthcare, Menlo Park, CA, United States

This work investigates the repeatability of CVR (induced by acetazolamide) using ASL on a healthy cohort. Single and multi-PLD PCASL data were collected before and after the administration of acetazolamide in two identical sessions. Results showed that the mean CVR of both ASL techniques were between 20% and 60% and not significantly different. Measurement using single-PLD PCASL demonstrated higher repeatability based on a lower coefficient of variation and a higher intraclass correlations.

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