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Abstract #3290

Robust Perfusion Parameter Quantification from 3D Single-Shot Multi-Delay ASL measurements

Oliver Maier1, Stefan M Spann1, Daniela Pinter2, Thomas Gattringer2, Lukas Pirpamer2, Christian Enzinger2, Josef Pfeuffer3, and Rudolf Stollberger1,4
1Institute of Medical Engineering, Graz University of Technology, Graz, Austria, 2Deptartment of General Neurology, Medical University of Graz, Graz, Austria, 3Application Development, Siemens Healthcare, Erlangen, Germany, 4Biotechmed, Graz, Austria

Multi-Delay single-shot ASL imaging provides accurate CBF and, in addition, ATT maps but the inherent low SNR can be challenging. State-of-the-art fitting techniques can improve the SNR in the estimated maps but typically suffer from spatial blurring. To this end, we propose a new reconstruction method with a joint TGV regularization on CBF and ATT to reconstruct sharp maps with improved noise suppression. Validation of the proposed method on a healthy subject and five stroke patients showed preservation of even small features in CBF and ATT while increasing SNR and sharpness over recent approaches.

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