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Abstract #3315

Quantification of collateral blood flow using intravoxel incoherent motion MRI in a canine large vessel occlusion model of slow and fast evolvers

Mohammed Salman Shazeeb1,2,3, Robert King1,2, Karl Helmer3, Josephine Kolstad1, Christopher Raskett1, Natacha Le Moan4, Jonathan A. Winger4, Lauren Kelly4, Ana Krtolica4, Nils Henninger1, and Matthew Gounis1
1University of Massachusetts Medical School, Worcester, MA, United States, 2Worcester Polytechnic Institute, Worcester, MA, United States, 3Massachusetts General Hospital & Harvard Medical School, Boston, MA, United States, 4Omniox Inc., San Carlos, CA, United States

In acute ischemic stroke due to large vessel occlusion (LVO), variability of infarct evolution observed in humans is closely captured by the canine LVO model, which can predict dogs to be slow or fast evolvers. The extent of collateral blood supply has shown good correlations with infarct growth rate. This study investigated the use of intravoxel incoherent motion (IVIM) MRI to quantify microvascular perfusion. Longitudinal IVIM parameters clearly differentiated between slow and fast evolvers depicting collateral blood flow changes, which can determine the severity of ischemic injury and also track longitudinal changes in response to therapeutic treatments/interventions in preclinical studies.

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