Abstract #3315

Quantification of collateral blood flow using intravoxel incoherent motion MRI in a canine large vessel occlusion model of slow and fast evolvers

Mohammed Salman Shazeeb^1,2,3, Robert King^1,2, Karl Helmer³, Josephine Kolstad¹, Christopher Raskett¹, Natacha Le Moan⁴, Jonathan A. Winger⁴, Lauren Kelly⁴, Ana Krtolica⁴, Nils Henninger¹, and Matthew Gounis¹

¹University of Massachusetts Medical School, Worcester, MA, United States, ²Worcester Polytechnic Institute, Worcester, MA, United States, ³Massachusetts General Hospital & Harvard Medical School, Boston, MA, United States, ⁴Omniox Inc., San Carlos, CA, United States

In acute ischemic stroke due to large vessel occlusion (LVO), variability of infarct evolution observed in humans is closely captured by the canine LVO model, which can predict dogs to be slow or fast evolvers. The extent of collateral blood supply has shown good correlations with infarct growth rate. This study investigated the use of intravoxel incoherent motion (IVIM) MRI to quantify microvascular perfusion. Longitudinal IVIM parameters clearly differentiated between slow and fast evolvers depicting collateral blood flow changes, which can determine the severity of ischemic injury and also track longitudinal changes in response to therapeutic treatments/interventions in preclinical studies.

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