Renal fibrosis is the final common consequence of chronic kidney disease (CKD) and is the mechanism of CKD progressing to end-stage renal failure. Here we employed ASL and IVIM to assess longitudinal changes of kidney perfusion to reflect renal fibrosis in an animal model of ADR nephropathy. A significant decline in renal microcirculation was detected in the ADR group compared with the sham group. Administration of VCP979 could prevent the renal perfusion, and the treatment response was also detected by the two imaging technology.
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