Meeting Banner
Abstract #3314

Noninvasive identification of renal perfusion in renal fibrosis of Adriamycin nephropathy by using ASL and IVIM-DWI imaging

Shudan Min1, Jilei Zhang2, and Shenghong Ju1
1Jiangsu Key Laboratory of Molecular Imaging and Functional Imaging,, Southeast University, Nanjing, Jiangsu, China, 2Clinical Science, Philips Healthcare, Shanghai, China

Renal fibrosis is the final common consequence of chronic kidney disease (CKD) and is the mechanism of CKD progressing to end-stage renal failure. Here we employed ASL and IVIM to assess longitudinal changes of kidney perfusion to reflect renal fibrosis in an animal model of ADR nephropathy. A significant decline in renal microcirculation was detected in the ADR group compared with the sham group. Administration of VCP979 could prevent the renal perfusion, and the treatment response was also detected by the two imaging technology.

This abstract and the presentation materials are available to 2020 meeting attendees and eLibrary customers only; a login is required.

Join Here